Previously, in December 2025, the EU Member State Committee (MSC) unanimously agreed to identify n-hexane as a Substance of Very High Concern (SVHC). This marks the first time a substance has been included in the SVHC candidate list due to its neurotoxicity posing an equivalent level of concern (ELOC), rather than being classified under traditional categories such as carcinogenic, mutagenic, or toxic for reproduction. Click here for the original ECHA text.

On February 4, 2026, the European Chemicals Agency (ECHA) announced that it has officially classified n-hexane as a Substance of Very High Concern (SVHC), as follows,

In the production of VCIP(INCI: TETRAHEXYLDECYL ASCORBATE/ASCORBYL TETRAISOPALMITATE, an oil-soluble vitamin C derivative), some older processes used n-hexane, potentially leaving an odor in the product. 

However, our product UNI_VCIP features an optimized production process that eliminates the use of n-hexane. 

UNI_VCIP is SVHC-Free, N-Hexane-Free, Worry-Free.

UNI_VCIP is safe, high-quality, and virtually odorless.

For more product information, please click on UNI_VCIP.

Additional information：

N-hexane is widely used in many industries, including the chemical industry. However, long-term exposure to n-hexane presents the following hazards:

1. Hazards to the nervous system: It primarily manifests as peripheral polyneuropathy, characterized by an insidious onset and slow progression. Initial symptoms include numbness, a cold sensation, and hyperhidrosis in the hands and feet. In later stages, it can lead to weakness in the extremities, muscle atrophy, and ultimately, limb paralysis.

2. Hazards to the cardiovascular system: It can cause cardiac arrhythmias, particularly ventricular fibrillation, and damage to myocardial cells.

3. Other hazards: These include reduced antibody levels. Skin contact may result in redness, blisters, and roughening.